Recognition of distinct cross-reactive virus-specific CD8+ T cells reveals a unique TCR signature in a clinical setting.

@article{Nguyen2014RecognitionOD,
  title={Recognition of distinct cross-reactive virus-specific CD8+ T cells reveals a unique TCR signature in a clinical setting.},
  author={Thi H O Nguyen and Louise C Rowntree and Daniel G. Pellicci and Nicola L. Bird and Andreas Handel and Lars Kjer-Nielsen and Katherine Kedzierska and Tom C. Kotsimbos and Nicole A Mifsud},
  journal={Journal of immunology},
  year={2014},
  volume={192 11},
  pages={5039-49}
}
Human CMV still remains problematic in immunocompromised patients, particularly after solid organ transplantation. CMV primary disease and reactivation greatly increase the risks associated with incidences of chronic allograft rejection and decreased survival in transplant recipients. But whether this is due to direct viral effects, indirect viral effects including cross-reactive antiviral T cell immunopathology, or a combination of both remains undetermined. In this article, we report the… CONTINUE READING

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