Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.

  title={Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.},
  author={Daniel B. Stetson and Ruslan Medzhitov},
  volume={24 1},
Nucleic acid recognition upon viral infection triggers type I interferon production. Viral RNA is detected by both endosomal, TLR-dependent and cytosolic, RIG-I/MDA5-dependent pathways. TLR9 is the only known sensor of foreign DNA; it is unknown whether innate immune recognition of DNA exists in the cytosol. Here we present evidence that cytosolic DNA activates a potent type I interferon response to the invasive bacterium Listeria monocytogenes. The noninvasive Legionella pneumophila triggers… CONTINUE READING
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