Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor.

@article{SantAngelo2002RecognitionOC,
  title={Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor.},
  author={Derek B Sant'Angelo and Eve Robinson and Charles A. Janeway and Lisa K. Denzin},
  journal={European journal of immunology},
  year={2002},
  volume={32 9},
  pages={2510-20}
}
CD4 T cells recognize peptides bound to major histocompatibility complex (MHC) class II molecules. Most MHC class II molecules have four binding pockets occupied by amino acids 1, 4, 6, and 9 of the minimal peptide epitope, while the residues at positions 2, 3, 5, 7, and 8 are available to interact with the T cell receptor (TCR). In addition MHC class II bound peptides have flanking residues situated outside of this peptide core. Here we demonstrate that the flanking residues of the conalbumin… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…