Recognition of central nervous system metastases in children with metastatic primary extracranial neuroblastoma.

@article{Blatt1997RecognitionOC,
  title={Recognition of central nervous system metastases in children with metastatic primary extracranial neuroblastoma.},
  author={Julie Blatt and Charles Fitz and Joseph Mirro},
  journal={Pediatric hematology and oncology},
  year={1997},
  volume={14 3},
  pages={233-41}
}
In children with primary extracranial neuroblastoma (NB), intrinsic central nervous system (CNS) metastases (brain parenchyma or leptomeninges) are thought to occur rarely. This study was done to evaluate our anecdotal experience, which suggested that CNS involvement is becoming more frequent. Reports of computed tomographic (CT) and magnetic resonance (MR) imaging scans, biopsies, cerebrospinal fluid (CSF) cytologies, and autopsies were reviewed for children with stage IV NB diagnosed in 1978… CONTINUE READING