Recognition of bacteria by inflammasomes.

  title={Recognition of bacteria by inflammasomes.},
  author={Jakob von Moltke and Janelle S. Ayres and Eric M. Kofoed and Joseph Chavarria-Smith and Russell E. Vance},
  journal={Annual review of immunology},
Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate immune responses, primarily by serving as platforms for the activation of inflammatory caspase proteases. One such caspase, CASPASE-1 (CASP1), initiates innate immune responses by cleaving pro-IL-1β and pro-IL-18, leading to their activation and release. CASP1 and another inflammatory caspase termed CASP11 can… 

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