Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-γ and attenuates the oxidative burst

@article{Johann2006RecognitionOA,
  title={Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-γ and attenuates the oxidative burst},
  author={Axel M. Johann and Andreas von Knethen and Dirk Lindemann and Bernhard Br{\"u}ne},
  journal={Cell Death and Differentiation},
  year={2006},
  volume={13},
  pages={1533-1540}
}
It is appreciated that phagocytosis of apoptotic cells (AC) is an immunological relevant process that shapes the pro- versus anti-inflammatory macrophage phenotype. It was our intention to study the respiratory burst, a prototype marker of macrophage activation, under the impact of AC. Following incubation of RAW264.7 macrophages with AC, we noticed attenuated production of reactive oxygen species (ROS) in response to PMA treatment, and observed a correlation between attenuated ROS formation… CONTINUE READING
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