Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.

@article{Johnson1993RecognitionOA,
  title={Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.},
  author={Richard Johnson and Alicja K. Trocha and Tom Buchanan and Bruce D. Walker},
  journal={Journal of virology},
  year={1993},
  volume={67 1},
  pages={438-45}
}
Human immunodeficiency virus type 1 (HIV-1) isolates exhibit extensive sequence variation, particularly in the gp120 subunit of the envelope glycoprotein, and the degree of this variation has raised questions as to whether conserved regions of the HIV-1 envelope can be recognized by the host immune response. A CD8+ cytotoxic T-lymphocyte (CTL) clone… CONTINUE READING