Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.

@article{Streeck2007RecognitionOA,
  title={Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.},
  author={Hendrik Streeck and Mathias Lichterfeld and Galit Alter and Angela Meier and Nickolas Teigen and Bader Yassine-Diab and Harlyn K Sidhu and Susan Little and Anthony Kelleher and Jean-pierre Routy and E. S. Rosenberg and Rafick Pierre S{\'e}kaly and Bruce D. Walker and Marcus Altfeld},
  journal={Journal of virology},
  year={2007},
  volume={81 14},
  pages={
          7725-31
        }
}
Human immunodeficiency virus type 1 (HIV-1)-specific immune responses during primary HIV-1 infection appear to play a critical role in determining the ultimate speed of disease progression, but little is known about the specificity of the initial HIV-1-specific CD8(+) T-cell responses in individuals expressing protective HLA class I alleles. Here we compared HIV-1-specific T-cell responses between subjects expressing the protective allele HLA-B27 or -B57 and subjects expressing nonprotective… CONTINUE READING

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