Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes.

@article{Kovach2014RecognitionOU,
  title={Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes.},
  author={Alexander R. Kovach and Kirsten E. Hoff and John T Canty and Jillian Orans and Richard G Brennan},
  journal={RNA},
  year={2014},
  volume={20 10},
  pages={
          1548-59
        }
}
Hfq is a post-transcriptional regulator that binds U- and A-rich regions of sRNAs and their target mRNAs to stimulate their annealing in order to effect translation regulation and, often, to alter their stability. The functional importance of Hfq and its RNA-binding properties are relatively well understood in Gram-negative bacteria, whereas less is known about the RNA-binding properties of this riboregulator in Gram-positive species. Here, we describe the structure of Hfq from the Gram… CONTINUE READING
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