Recognition of RNA polymerase II carboxy-terminal domain by 3′-RNA-processing factors

@article{Meinhart2004RecognitionOR,
  title={Recognition of RNA polymerase II carboxy-terminal domain by 3′-RNA-processing factors},
  author={A. Meinhart and P. Cramer},
  journal={Nature},
  year={2004},
  volume={430},
  pages={223-226}
}
During transcription, RNA polymerase (Pol) II synthesizes eukaryotic messenger RNA. Transcription is coupled to RNA processing by the carboxy-terminal domain (CTD) of Pol II, which consists of up to 52 repeats of the sequence Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7 (refs 1, 2). After phosphorylation, the CTD binds tightly to a conserved CTD-interacting domain (CID) present in the proteins Pcf11 and Nrd1, which are essential and evolutionarily conserved factors for polyadenylation-dependent… Expand
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