Recognition of RNA polymerase II carboxy-terminal domain by 3′-RNA-processing factors

@article{Meinhart2004RecognitionOR,
  title={Recognition of RNA polymerase II carboxy-terminal domain by 3′-RNA-processing factors},
  author={A. Meinhart and P. Cramer},
  journal={Nature},
  year={2004},
  volume={430},
  pages={223-226}
}
During transcription, RNA polymerase (Pol) II synthesizes eukaryotic messenger RNA. Transcription is coupled to RNA processing by the carboxy-terminal domain (CTD) of Pol II, which consists of up to 52 repeats of the sequence Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7 (refs 1, 2). After phosphorylation, the CTD binds tightly to a conserved CTD-interacting domain (CID) present in the proteins Pcf11 and Nrd1, which are essential and evolutionarily conserved factors for polyadenylation-dependent… Expand
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306 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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306 Citations

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Citation Type

Role of the RNA polymerase II C-terminal domain in transcription termination and function of Spt5 in 3' RNA-processing factor recruitment.
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Snapshots of the RNA Processing Factor SCAF8 Bound to Different Phosphorylated Forms of the Carboxyl-terminal Domain of RNA Polymerase II*
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RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.
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  • Chemistry, Medicine
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The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation.
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Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3′-end processing
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TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.
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Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription.
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  • Highly Influenced
Phosphoserines of the carboxy terminal domain of RNA polymerase II are involved in the interaction with transcription-associated proteins (TAPs).
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The RNA polymerase II CTD coordinates transcription and RNA processing.
  • 464
  • PDF
RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc 7
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References

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