Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation

  title={Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation},
  author={Huilin Huang and Hengyou Weng and Wenju Sun and X D Qin and Hailing Shi and Huizhe Wu and Boxuan Simen Zhao and Ana Cristina Mesquita and Chang Liu and Celvie L. Yuan and Yueh-Chiang Hu and Stefan H{\"u}ttelmaier and Jennifer R. Skibbe and Rui Su and Xiaolan Deng and Lei Dong and Miao Sun and Chenying Li and Sigrid Nachtergaele and Yungui Wang and Chen Hu and Kyle Ferchen and Kenneth D. Greis and Xi Jiang and Min-jie Wei and Liang-Hu Qu and Jun-Lin Guan and Chuan He and Jianhua Yang and Jianjun Chen},
  booktitle={Nature Cell Biology},
N 6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence. In contrast to the mRNA-decay-promoting function of YTH domain… CONTINUE READING
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YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4NOT deadenylase complex

  • H Du
  • Nat Commun
  • 2016

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