Recognition of HLA-B27 and related antigen by a monoclonal antibody.

  title={Recognition of HLA-B27 and related antigen by a monoclonal antibody.},
  author={Shirley Ellis and Christopher Michael Taylor and Andrew J McMichael},
  journal={Human immunology},
  volume={5 1},
A monoclonal antibody that binds specifically to HLA-B27, B7, and B22 is described. Binding to B27 appeared to be slightly stronger than to B7 and stronger than to B22 in an indirect binding assay, but no difference in B7 and B27 binding could be detected by Scatchard analysis. No distinction could be made between B27 on cells from normal and from ankylosing spondylitis patients in any assay system. The antibody, which was not cytotoxic, blocked complement-dependent cytolysis mediated by human… CONTINUE READING


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