Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells.

@article{Fisch1990RecognitionBH,
  title={Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells.},
  author={Paul Fisch and Miroslav Malkovsk{\'y} and Steve G. Kovats and Els Sturm and Eric Braakman and Bruce S Klein and Stephan D. Voss and L W Morrissey and Robert Demars and William J. Welch},
  journal={Science},
  year={1990},
  volume={250 4985},
  pages={1269-73}
}
All human gamma delta T cells coexpressing the products of the variable (V) region T cell receptor (TCR) gene segments V gamma 9 and V delta 2 recognize antigens from mycobacterial extracts and Daudi cells. Exogenous and endogenous ligands on the cell surface, homologous to the groEL heat shock family, induced reactivities that resembled superantigen responses in this major subset of human peripheral blood gamma delta T cells. Stimulation of human V gamma 9/V delta 2 T cells is not restricted… CONTINUE READING