Recognition by TNF-α of the GPI-anchor glycan induces apoptosis of U937 cells

@inproceedings{Fukushima2004RecognitionBT,
  title={Recognition by TNF-α of the GPI-anchor glycan induces apoptosis of U937 cells},
  author={Keiko Fukushima and Chikako Ishiyama and Katsuko Yamashita},
  year={2004}
}
Abstract Tumor necrosis factor-α (TNF-α) binds to TNF-α receptors (TNFR) to produce a hexameric (TNF-α) 3 –(TNFR) 3 structure that stimulates apoptosis. We found by using ELISA that TNF-α binds to the glycosylphosphatidylinositol (GPI) anchor glycans of carcinoembryonic antigen, human placental alkaline phosphatase (hAP), and Tamm–Horsfall glycoprotein. These binding abilities were inhibited by 10 −6  M mannose-6-phosphate. Treatment of hAP with mild acid and phosphatase, which releases the N… CONTINUE READING

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