Recognition and phagocytosis of cells undergoing apoptosis.

  title={Recognition and phagocytosis of cells undergoing apoptosis.},
  author={John Savill},
  journal={British medical bulletin},
  volume={53 3},
In vivo, the normal fate of cells undergoing apoptosis is recognition, uptake and degradation of the intact dying cell by phagocytes. Cell clearance by this mechanism is fast, efficient and injury-limiting, being mediated by macrophages and semi-professional phagocytes. Apoptotic cells are marked for disposal by mechanisms which remain poorly understood, although in some circumstances surface sugar changes and exposure of phosphatidylserine lead to recognition by uncharacterised phagocyte… CONTINUE READING

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