Recognition and maturation of effector RNAs in a CRISPR interference pathway

@article{Gesner2011RecognitionAM,
  title={Recognition and maturation of effector RNAs in a CRISPR interference pathway},
  author={Emily M. Gesner and M. J. Schellenberg and E. Garside and Mark M George and A. MacMillan},
  journal={Nature Structural \&Molecular Biology},
  year={2011},
  volume={18},
  pages={688-692}
}
In bacteria and archaea, small RNAs derived from clustered, regularly interspaced, short palindromic repeat (CRISPR) loci are involved in an adaptable and heritable gene-silencing pathway. Resistance to phage infection is conferred by the incorporation of short invading DNA sequences into the genome as CRISPR spacer elements separated by short repeat sequences. Processing of long primary transcripts (pre-crRNAs) containing these repeats by an RNA endonuclease generates the mature effector RNAs… Expand
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Cutting it close: CRISPR-associated endoribonuclease structure and function.
Recognition and cleavage of a nonstructured CRISPR RNA by its processing endoribonuclease Cas6.
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