Recognition and maturation of effector RNAs in a CRISPR interference pathway

@article{Gesner2011RecognitionAM,
  title={Recognition and maturation of effector RNAs in a CRISPR interference pathway},
  author={Emily M. Gesner and Matthew J. Schellenberg and Erin L. Garside and Mark M George and Andrew M. MacMillan},
  journal={Nature Structural \&Molecular Biology},
  year={2011},
  volume={18},
  pages={688-692}
}
In bacteria and archaea, small RNAs derived from clustered, regularly interspaced, short palindromic repeat (CRISPR) loci are involved in an adaptable and heritable gene-silencing pathway. Resistance to phage infection is conferred by the incorporation of short invading DNA sequences into the genome as CRISPR spacer elements separated by short repeat sequences. Processing of long primary transcripts (pre-crRNAs) containing these repeats by an RNA endonuclease generates the mature effector RNAs… 
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