Recognition and binding of mismatch repair proteins at an oncogenic hot spot

@article{Edelbrock2004RecognitionAB,
  title={Recognition and binding of mismatch repair proteins at an oncogenic hot spot},
  author={Michael Edelbrock and Huiling He and Allen G Schroering and Martha J Fernstrom and Sangeetha Bathala and Kandace J Williams},
  journal={BMC Molecular Biology},
  year={2004},
  volume={6},
  pages={6 - 6}
}
The current investigation was undertaken to determine key steps differentiating G:T and G:A repair at the H-ras oncogenic hot spot within the nuclear environment because of the large difference in repair efficiency of these two mismatches. Electrophoretic mobility shift (gel shift) experiments demonstrate that DNA containing mismatched bases are recognized and bound equally efficiently by hMutSα in both MMR proficient and MMR deficient (hMLH1-/-) nuclear extracts. Competition experiments… CONTINUE READING

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