Recognition Functions of Pentameric C-Reactive Protein in Cardiovascular Disease

  title={Recognition Functions of Pentameric C-Reactive Protein in Cardiovascular Disease},
  author={Alok Agrawal and Toh B. Gang and Antonio E. Rusi{\~n}ol},
  booktitle={Mediators of inflammation},
C-reactive protein (CRP) performs two recognition functions that are relevant to cardiovascular disease. First, in its native pentameric conformation, CRP recognizes molecules and cells with exposed phosphocholine (PCh) groups, such as microbial pathogens and damaged cells. PCh-containing ligand-bound CRP activates the complement system to destroy the ligand. Thus, the PCh-binding function of CRP is defensive if it occurs on foreign pathogens because it results in the killing of the pathogen… CONTINUE READING
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