Reclassification of genetic-based risk predictions as GWAS data accumulate

Abstract

Disease risk assessments based on common genetic variation have gained widespread attention and use in recent years. The clinical utility of genetic risk profiles depends on the number and effect size of identified loci, and how stable the predicted risks are as additional loci are discovered. Changes in risk classification for individuals over time would… (More)
DOI: 10.1186/s13073-016-0272-5

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