Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation

  title={Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation},
  author={M. Or-Guil and N. Wittenbrink and A. Weiser and J. Schuchhardt},
  journal={Immunological Reviews},
  • M. Or-Guil, N. Wittenbrink, +1 author J. Schuchhardt
  • Published 2007
  • Biology, Medicine
  • Immunological Reviews
  • Summary:  Optimization of antibody affinity is a hallmark of the humoral immune response. It takes place in hundreds of transient microstructures called germinal centers (GCs). Their function and time‐dependent behavior are subjects of active investigation. According to a generally accepted notion, their individual kinetics follows the average kinetics of all GCs present in the observed lymphatic tissue. In this review, we challenge this view and point out, with the help of mathematical… CONTINUE READING
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