Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation

@article{OrGuil2007RecirculationOG,
  title={Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation},
  author={Michal Or-Guil and Nicole Wittenbrink and Armin A. Weiser and Johannes Schuchhardt},
  journal={Immunological Reviews},
  year={2007},
  volume={216}
}
Summary:  Optimization of antibody affinity is a hallmark of the humoral immune response. It takes place in hundreds of transient microstructures called germinal centers (GCs). Their function and time‐dependent behavior are subjects of active investigation. According to a generally accepted notion, their individual kinetics follows the average kinetics of all GCs present in the observed lymphatic tissue. In this review, we challenge this view and point out, with the help of mathematical… Expand
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39 Citations
Background Citations
19
Methods Citations
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Results Citations
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39 Citations

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Citation Type

Germinal-center organization and cellular dynamics.
TLDR
A model in which dark- and light-zone cells are morphologically similar, proliferation occurs in both zones, and GC B cells compete for T cell help as well as antigen is discussed. Expand
How oligoclonal are germinal centers? A new method for estimating clonal diversity from immunohistological sections
BackgroundThe germinal center (GC) reaction leads to antibody affinity maturation and generation of memory B cells, but its underlying mechanisms are poorly understood. To assemble this puzzle,… Expand
Reassessing Germinal Centre Reaction Concepts
TLDR
An extended mathematical model is proposed that includes an estimation of errors created by data sampling, two new parameters that take into account possible mistakes in classification of single population GC sections, and the likely variability in the number of seeding B cells. Expand
A Major Hindrance in Antibody Affinity Maturation Investigation: We Never Succeeded in Falsifying the Hypothesis of Single-Step Selection
TLDR
The single-step selection concept is proposed to be a null-hypothesis which should be attempted to be falsified, and the focus on a process of random non-directed acquisition of mutations, which minimizes the need for unverified assumptions. Expand
Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing
TLDR
A computational model that simulates affinity maturation in a single GC while tracking individual subclones in terms of abundancy and affinity is developed and suggests that selecting highly abundant subClones from repertoire sequencing experiments would not always lead to the high(est) affinity B cells. Expand
Chapter 33 – Mucosal B Cell Differentiation and Regulation
TLDR
This chapter describes how IgA B cells are activated, distributed, and maintained as either long-lived plasma cells or memory B cells, and it reviews recent developments in the field. Expand
Optimality of Mutation and Selection in Germinal Centers
TLDR
A coarse-grained model is presented to calculate the B cell population development in affinity maturation, which allows a comprehensive analysis of its parameter space to look for optimal values of mutation rate, selection strength, and initial antibody-antigen binding level that maximize the affinity improvement. Expand
Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution.
TLDR
The study of lymphocyte repertoires will enable clinical immunologists to develop better therapeutic monoclonal antibodies, vaccines, transplantation donor-recipient matching protocols, and other immune intervention strategies and challenges the theoretical immunology community to develop methods for data organization and analysis. Expand
The mechanisms of thermosensitivity of human andbony fish activation-induced cytidine deaminase(AID)
TLDR
The aim was to elucidate the relationship between thermosensitivity of AID and its primary structure, by identifying region(s and/or residue) within the enzyme that affect thermosensitive, and found that this characteristic is mostly determined by the C-terminus in the sense that swapping this region resulted in transferring thermos sensitivity patterns from the donor enzyme. Expand
Follicular dendritic cells in health and disease
TLDR
A better understanding of FDCs should permit better regulation of Ab responses to suit the therapeutic manipulation of regulated and dysregulated immune responses. Expand
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