Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation

@article{OrGuil2007RecirculationOG,
  title={Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation},
  author={M. Or-Guil and N. Wittenbrink and Armin A. Weiser and J. Schuchhardt},
  journal={Immunological Reviews},
  year={2007},
  volume={216}
}
Summary:  Optimization of antibody affinity is a hallmark of the humoral immune response. It takes place in hundreds of transient microstructures called germinal centers (GCs). Their function and time‐dependent behavior are subjects of active investigation. According to a generally accepted notion, their individual kinetics follows the average kinetics of all GCs present in the observed lymphatic tissue. In this review, we challenge this view and point out, with the help of mathematical… Expand
39 Citations
Germinal-center organization and cellular dynamics.
  • 802
How oligoclonal are germinal centers? A new method for estimating clonal diversity from immunohistological sections
  • 10
Optimality of Mutation and Selection in Germinal Centers
  • 38
  • PDF
Follicular dendritic cells in health and disease
  • 56
...
1
2
3
4
...

References

SHOWING 1-10 OF 70 REFERENCES
Differentiation of the Secondary B‐Lymphocyte Repertoire: The Germinal Center Reaction
  • G. Nossal
  • Biology, Medicine
  • Immunological reviews
  • 1994
  • 83
A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation.
  • 52
  • Highly Influential
  • PDF
Dynamics of one-pass germinal center models: Implications for affinity maturation
  • 42
  • PDF
A mathematical model for germinal centre kinetics and affinity maturation.
  • 38
  • Highly Influential
Imaging of Germinal Center Selection Events During Affinity Maturation
  • 688
A mathematical model on germinal center kinetics and termination.
  • 67
  • PDF
An analysis of B cell selection mechanisms in germinal centers.
  • 117
  • PDF
Somatic hypermutation in B cells: an optimal control treatment.
  • 159
  • PDF
...
1
2
3
4
5
...