• DOI:10.1111/j.1600-065X.2007.00507.x
Corpus ID: 37636392

Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation

@article{OrGuil2007RecirculationOG,
  title={Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation},
  author={M. Or-Guil and N. Wittenbrink and A. Weiser and J. Schuchhardt},
  journal={Immunological Reviews},
  year={2007},
  volume={216}
}

M. Or-Guil, N. Wittenbrink, +1 author J. Schuchhardt

Published 2007

Biology, Medicine

Immunological Reviews

Summary:  Optimization of antibody affinity is a hallmark of the humoral immune response. It takes place in hundreds of transient microstructures called germinal centers (GCs). Their function and time‐dependent behavior are subjects of active investigation. According to a generally accepted notion, their individual kinetics follows the average kinetics of all GCs present in the observed lymphatic tissue. In this review, we challenge this view and point out, with the help of mathematical… CONTINUE READING

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