Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure.

@article{Barth2011ReciprocalTR,
  title={Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure.},
  author={Andreas S. Barth and Ami Kumordzie and C. Frangakis and Kenneth B. Margulies and Thomas P. Cappola and Gordon F. Tomaselli},
  journal={Circulation. Cardiovascular genetics},
  year={2011},
  volume={4 5},
  pages={475-83}
}
BACKGROUND Systolic heart failure (HF) is a complex systemic syndrome that can result from a wide variety of clinical conditions and gene mutations. Despite phenotypic similarities, characterized by ventricular dilatation and reduced contractility, the extent of common and divergent gene expression between different forms of HF remains a matter of intense debate. METHODS AND RESULTS Using a meta-analysis of 28 experimental (mouse, rat, dog) and human HF microarray studies, we demonstrate that… CONTINUE READING
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2nd. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support

  • SJ Matkovich, DJ Van Booven, +7 authors GW Dorn
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