Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.

@article{Chew2005ReciprocalTR,
  title={Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.},
  author={Joon-Lin Chew and Yuin-Han Loh and Wensheng Zhang and Xi Chen and W Tam and Leng-Siew Yeap and Pin Li and Yen-Sin Ang and Bing Lim and Paul Robson and Huck-Hui Ng},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 14},
  pages={6031-46}
}
Embryonic stem cells (ESCs) are pluripotent cells that can either self-renew or differentiate into many cell types. Oct4 and Sox2 are transcription factors essential to the pluripotent and self-renewing phenotypes of ESCs. Both factors are upstream in the hierarchy of the transcription regulatory network and are partners in regulating several ESC-specific genes. In ESCs, Sox2 is transcriptionally regulated by an enhancer containing a composite sox-oct element that Oct4 and Sox2 bind in a… CONTINUE READING
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Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex

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