Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning

@inproceedings{CervantesSandoval2017ReciprocalSB,
  title={Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning},
  author={Isaac Cervantes-Sandoval and Anna Phan and Molee Chakraborty and Ronald L. Davis},
  booktitle={eLife},
  year={2017}
}
Current thought envisions dopamine neurons conveying the reinforcing effect of the unconditioned stimulus during associative learning to the axons of Drosophila mushroom body Kenyon cells for normal olfactory learning. Here, we show using functional GFP reconstitution experiments that Kenyon cells and dopamine neurons from axoaxonic reciprocal synapses. The dopamine neurons receive cholinergic input via nicotinic acetylcholine receptors from the Kenyon cells; knocking down these receptors… CONTINUE READING
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