Reciprocal sympatho-sensory control: functional role of nucleotides and calcitonin gene-related peptide in a peripheral neuroeffector junction

  title={Reciprocal sympatho-sensory control: functional role of nucleotides and calcitonin gene-related peptide in a peripheral neuroeffector junction},
  author={M. Ver{\'o}nica Donoso and Daniel Hermosilla and Camilo Navarrete and P. {\'A}lvarez and Juan Pablo Huidobro-Toro},

Heteroreceptors Modulating CGRP Release at Neurovascular Junction: Potential Therapeutic Implications on Some Vascular-Related Diseases

Although under physiological conditions, CGRP seems not to play an important role in vascular tone regulation, this peptide has been strongly related as a key player in migraine and other vascular-related disorders.

Increased ATP and ADO Overflow From Sympathetic Nerve Endings and Mesentery Endothelial Cells Plus Reduced Nitric Oxide Are Involved in Diabetic Neurovascular Dysfunction

Findings provide neurochemical support for the diabetes-induced neuropathy and show that mesenteric endothelial cells alterations in response to mechanical stimulation are compatible with the endothelial dysfunction related to vascular disease progress.

Perivascular Innervation: A Multiplicity of Roles in Vasomotor Control and Myoendothelial Signaling

Current understanding of signaling events that originate within SMCs in response to perivascular neurotransmission in light of EC feedback are synthesized.

Rat mesenteric small artery neurogenic dilatation is predominantly mediated by β1‐adrenoceptors in vivo

Evidence is provided indicating that in vivo electrical perivascular nerve stimulation in rat mesenteric small arteries causes a large β1‐adrenoceptor‐mediated vasodilatation, which contrasts with a smaller vasodILatation caused by endogenous CGRP that is only visible after inhibition of Y1 NPY receptors.

P2X1 Receptors Localized in Lipid Rafts Mediate ATP Motor Responses in the Human Vas Deferens Longitudinal Muscles1

In conclusion, ATP plays a key role in human vas deferens contractile responses of the longitudinal smooth muscle layer, an effect mediated through P2X1Rs.

Sympathetic and sensory-motor nerves in peripheral small arteries.

This review highlights what has been learned during recent years with respect to development of small arteries and their innervation, some aspects of excitation-release coupling, interaction between sympathetic and sensory-motor nerves, cross-talk between endothelium and vascular nerves, and some aspect of their role in vascular inflammation and hypertension.

Capsaicin-Induced Activation of ERK1/2 and Its Involvement in GAP-43 Expression and CGRP Depletion in Organotypically Cultured DRG Neurons

The results of the present study imply that CAP at different concentrations has different effects on GAP-43 expression and CGRP depletion, which were involved in the activation of ERK1/2 in organotypically cultured DRG neurons stimulated with CAP.

Purinergic signalling in the reproductive system in health and disease

There are multiple roles for purinergic signalling in both male and female reproductive organs, and changes in purinoceptor expression occur in pathophysiological conditions, including pre-eclampsia, cancer and pain.



Bradykinin activates a cross-signaling pathway between sensory and adrenergic nerve endings in the heart: a novel mechanism of ischemic norepinephrine release?

BK is a potent releaser of NE from guinea pig heart synaptosomes and is likely to release NE in the heart in part by first liberating calcitonin gene-related peptide and Substance P from sensory nerve endings; these neuropeptides then stimulate specific receptors on sympathetic terminals.

Inhibitory effect of calcitonin gene-related peptide on excitation and contraction of smooth muscles of the rat vas deferens.

Results indicate that CGRP does not affect the release of a sympathetic neurotransmitter and appears to attenuate the contraction of the rat vas deferens through suppression of both the excitability and excitation-contraction coupling of the smooth muscle.

Modulation of sympathetic vasoconstriction by sensory nerves and nitric oxide in rat irideal arterioles.

  • C. HillD. Gould
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1995
In arterioles from control rats, both the substance P analog Sar9 and calcitonin gene-related peptide (CGRP) were effective in inhibiting nerve-mediated vasoconstriction, which suggested that the mechanism of action of both peptides involved the release of nitric oxide.

Proton Acts as a Neurotransmitter for Nicotine-Induced Adrenergic and Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in the Rat Mesenteric Artery

Results indicate that nicotine initially stimulates adrenergic nerves via nicotinic α3β4-receptors to release protons and thereby induces CGRPergic nerve-mediated vasodilation via TRPV1.

Temperature Dependency of Basal and Evoked Release of Amino Acids and Calcitonin Gene-Related Peptide from Rat Dorsal Spinal Cord

The pronounced temperature dependency of evoked transmitter release between 40 and 34°C is consistent with the profound cerebral protection observed with mild hypothermia in which metabolic activity is only slightly depressed.

Increased Blood Pressure in α-Calcitonin Gene–Related Peptide/Calcitonin Gene Knockout Mice

Results indicate for the first time that α- CGRP may be involved in the long-term regulation of resting BP and suggest that these mice are particularly sensitive to challenges to BP homeostasis because of the loss of a compensatory vasodilator mechanism.

Pharmacological evidence for CGRP uptake into perivascular capsaicin sensitive nerve terminals

Evidence is presented for uptake of the 37 amino acid neuropeptide, calcitonin gene‐related peptide (CGRP) into perivascular terminals of capsaicin sensitive nerve fibres, innervating the guinea‐pig basilar artery.