Reciprocal-space solvent flattening

@inproceedings{Terwilliger1999ReciprocalspaceSF,
  title={Reciprocal-space solvent flattening},
  author={Thomas C. Terwilliger},
  booktitle={Acta crystallographica. Section D, Biological crystallography},
  year={1999}
}
Solvent flattening is a powerful tool for improving crystallographic phases for macromolecular structures obtained at moderate resolution, but uncertainties in the optimal weighting of experimental phases and modified phases make it difficult to extract all the phase information possible. Solvent flattening is essentially an iterative method for maximizing a likelihood function which consists of (i) experimental phase information and (ii) information on the likelihood of various arrangements of… CONTINUE READING

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