Reciprocal relation between VEGF and NO in the regulation of endothelial integrity

Abstract

Balloon angioplasty disrupts the protective endothelial lining of the arterial wall, rendering arteries susceptible to thrombosis and intimal thickening. We show here that vascular endothelial growth factor (VEGF), an endothelial cell mitogen, is upregulated in medial smooth muscle cells of the arterial wall in response to balloon injury. Both protein… (More)
DOI: 10.1038/nm0897-879

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