Reciprocal regulation via protein-protein interaction between c-Myc and p21(cip1/waf1/sdi1) in DNA replication and transcription.

@article{Kitaura2000ReciprocalRV,
  title={Reciprocal regulation via protein-protein interaction between c-Myc and p21(cip1/waf1/sdi1) in DNA replication and transcription.},
  author={Hirotake Kitaura and Mariko Shinshi and Yasuo Uchikoshi and Toshio Ono and Sanae M. M. Iguchi-Ariga and Hiroyoshi Ariga},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 14},
  pages={
          10477-83
        }
}
The c-myc protooncogene product (c-Myc) is a transcription factor and is rapidly induced in resting cells following various mitogenic stimuli. c-Myc is thus suggested to play an important role in the transition from quiescence to proliferation. Despite numerous studies, including those on the connection between cyclin E/cyclin-dependent kinase 2 and c-Myc, little has been clarified about c-Myc in terms of the cell cycle regulation. Here we show that c-Myc can directly bind to the carboxyl… CONTINUE READING

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