Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

@article{Joseph2003ReciprocalRO,
  title={Reciprocal regulation of inflammation and lipid metabolism by liver X receptors},
  author={S. Joseph and A. Castrillo and B. Laffitte and D. Mangelsdorf and P. Tontonoz},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={213-219}
}
Macrophages have important roles in both lipid metabolism and inflammation and are central to the pathogenesis of atherosclerosis. The liver X receptors (LXRs) are established mediators of lipid-inducible gene expression, but their role in inflammation and immunity is unknown. We demonstrate here that LXRs and their ligands are negative regulators of macrophage inflammatory gene expression. Transcriptional profiling of lipopolysaccharide (LPS)-induced macrophages reveals reciprocal LXR… Expand
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