Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia.

@article{Naura2008ReciprocalRO,
  title={Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia.},
  author={Amarjit S Naura and Rahul Datta and Chetan P Hans and Mourad Zerfaoui and Bashir M. Rezk and Youssef Errami and Mustapha Oumouna and Khalid Matrougui and A Hamid Boulares},
  journal={The European respiratory journal},
  year={2008},
  volume={33 2},
  pages={
          252-62
        }
}
Inducible nitric oxide synthase (iNOS) inhibition was recently shown to exert no effect on allergen challenge in human asthma, raising serious concerns about the role of the protein in the disease. The present study investigated the role of iNOS in ovalbumin-induced eosinophilia from the perspective of its relationship with poly(ADP-ribose) polymerase-1 (PARP-1) and oxidative DNA damage. A mouse model of ovalbumin-induced eosinophilia was used to conduct the studies. iNOS-associated protein… CONTINUE READING

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