Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.

@article{Beaven2013ReciprocalRO,
  title={Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.},
  author={Simon W. Beaven and Aleksey V Matveyenko and Kevin Wroblewski and Lily C Chao and Damien C Wilpitz and Tu Wen Hsu and Jacob F Lentz and Brian M Drew and Andrea L. Hevener and Peter Tontonoz},
  journal={Cell metabolism},
  year={2013},
  volume={18 1},
  pages={106-17}
}
Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the metabolic syndrome is unclear. We show that LXRs modulate key aspects of the metabolic syndrome in mice. LXRαβ-deficient-ob/ob (LOKO) mice remain obese but show reduced hepatic steatosis and improved insulin sensitivity compared to ob/ob mice. Impaired hepatic lipogenesis in LOKO mice is accompanied by reciprocal increases in adipose lipid storage, reflecting tissue-selective effects on the SREBP, PPAR… CONTINUE READING
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