Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

@article{Tebbutt2002ReciprocalRO,
  title={Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice},
  author={Niall C. Tebbutt and Andrew S. Giraud and Melissa Inglese and Brendan J Jenkins and Paul Waring and Fiona J. Clay and Sina Malki and Barbara M. Alderman and Dianne Grail and Fr{\'e}d{\'e}ric Hollande and Joan K. Heath and Matthias Ernst},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={1089-1097}
}
The intracellular signaling mechanisms that specify tissue-specific responses to the interleukin-6 (IL-6) family of cytokines are not well understood. Here, we evaluated the functions of the two major signaling pathways, the signal transducers and activators of transcription 1 and 3 (STAT1/3) and the Src-homology tyrosine phosphatase 2 (SHP2)-Ras-ERK, emanating from the common signal transducer, gp130, in the gastrointestinal tract. Gp130757F mice, with a 'knock-in' mutation abrogating SHP2-Ras… CONTINUE READING
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