Reciprocal regulation of endothelin-1 and endothelial constitutive NOS in proliferating endothelial cells.

@article{Flowers1995ReciprocalRO,
  title={Reciprocal regulation of endothelin-1 and endothelial constitutive NOS in proliferating endothelial cells.},
  author={Melody A Flowers and Ying Wang and Richard J. Stewart and Bina S Patel and Philip A. Marsden},
  journal={The American journal of physiology},
  year={1995},
  volume={269 6 Pt 2},
  pages={H1988-97}
}
The expression of endothelin-1 (ET-1) and endothelial constitutive nitric oxide synthase (ecNOS) was assessed in two independent in vitro models: asynchronously differentially proliferating cultures and wounded endothelial cell monolayers. Northern blot analysis of RNA isolated from preconfluent, confluent, and postconfluent cells revealed a fourfold rise in ET-1 mRNA transcripts, whereas levels of ecNOS mRNA transcripts were reduced twofold in proliferating cells. Nuclear run-off analysis… CONTINUE READING
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