Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs

  title={Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs},
  author={Jing-Wen Lyu and Bo Yuan and Tian-Lin Cheng and Zi-long Qiu and Wenhao Zhou},
  booktitle={Scientific reports},
MeCP2 encodes a methyl-CpG-binding protein that plays a critical role in repressing gene expression, mutations of which lead to Rett syndrome and autism. PTEN is a critical tumor suppressor gene that is frequently mutated in human cancers and autism spectrum disorders. Various studies have shown that both MeCP2 and PTEN proteins play important roles in brain development. Here we find that MeCP2 and PTEN reciprocally regulate expression of each other via microRNAs. Knockdown of MeCP2 leads to… CONTINUE READING
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The authors declare no competing financial interests

Klein, 10 M.E.etal.HomeostaticregulationofMeCP2expressionbya, +12 authors approved final manuscript. Additional Information Competing interests
How to cite this article: Lyu, J.-W. et al. Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs. Sci. Rep. 6, 20392; doi: 10.1038/srep20392 • 2016

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