Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2.

@article{Dann2015ReciprocalRO,
  title={Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2.},
  author={Stephen G Dann and Michael Ryskin and Anthony M. Barsotti and Jonathon Golas and Celine Shi and Miriam Miranda and Christine Hosselet and Luanna Lemon and Judy Lucas and Maha A Karnoub and Fang Wang and Jeremy S Myers and Scott J. Garza and Maximillian T. Follettie and Kenneth G. Geles and Anke Klippel and Robert A. Rollins and Valeria R. Fantin},
  journal={The EMBO journal},
  year={2015},
  volume={34 13},
  pages={1773-85}
}
Lat1 (SLC7A5) is an amino acid transporter often required for tumor cell import of essential amino acids (AA) including Methionine (Met). Met is the obligate precursor of S-adenosylmethionine (SAM), the methyl donor utilized by all methyltransferases including the polycomb repressor complex (PRC2)-specific EZH2. Cell populations sorted for surface Lat1… CONTINUE READING