Reciprocal regulation of NO signaling and TXNIP expression in humans: impact of aging and ramipril therapy.

@article{Sverdlov2013ReciprocalRO,
  title={Reciprocal regulation of NO signaling and TXNIP expression in humans: impact of aging and ramipril therapy.},
  author={Aaron L Sverdlov and Wai P.A. Chan and Nathan Edward Kevin Procter and Yuliy Y. Chirkov and Doan T. M. Ngo and John David Horowitz},
  journal={International journal of cardiology},
  year={2013},
  volume={168 5},
  pages={
          4624-30
        }
}
BACKGROUND Impaired tissue responsiveness to nitric oxide (NO) occurs in many cardiovascular diseases as well as with advanced age and is a correlate of poor outcomes. This phenomenon results from oxidative stress, with NO "scavenging" and dysfunction of soluble guanylate cyclase (sGC). Thioredoxin-interacting protein (TXNIP) is a major intracellular regulator of inflammatory activation and redox stress, but its interactions with NO/sGC are poorly understood. We have now evaluated the… CONTINUE READING
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