Reciprocal raft-receptor interactions and the assembly of adhesion complexes.

  title={Reciprocal raft-receptor interactions and the assembly of adhesion complexes.},
  author={Tony J C Harris and C S Siu},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={24 11},
Cell adhesion complexes are critical for the physical coordination of cell-cell interactions and the morphogenesis of tissues and organs. Many adhesion receptors are anchored to the plasma membrane by a glycosylphosphatidylinositol (GPI) moiety and are thereby partitioned into membrane rafts. In this review, we focus on reciprocal interactions between rafts and adhesion molecules, leading to receptor clustering and raft expansion and stability. A model for a three-stage adhesion complex… CONTINUE READING

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