Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions.

@article{Ross1998ReciprocalMO,
  title={Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions.},
  author={Gregory M Ross and Igor L. Shamovsky and Gail M. Lawrance and Mark Solc and Suzanne M. Dostaler and Donald F. Weaver and Richard J. Riopelle},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 3},
  pages={890-8}
}
Equilibrium binding of 125I-nerve growth factor (125I-NGF) to cells coexpressing the tyrosine kinase receptor A (TrkA) and common neurotrophin receptor (p75NTR), cells coexpressing both receptors where p75NTR is occupied, and cells expressing only p75NTR, revealed reciprocal modulation of receptor affinity states. Analysis of receptor affinity states in PC12 cells, PC12 cells in the presence of brain-derived neurotrophic factor (BDNF), and PC12nnr5 cells suggested that liganded and unliganded… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…