Reciprocal modulation by sex steroid and calciotrophic hormones of skeletal cell proliferation.

@article{Smjen1990ReciprocalMB,
  title={Reciprocal modulation by sex steroid and calciotrophic hormones of skeletal cell proliferation.},
  author={Dalia S{\"o}mjen and Arie Harell and N Jaccard and Yosef Weisman and Alvin M. Kaye},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1990},
  volume={37 4},
  pages={491-9}
}
We have demonstrated previously that 17 beta-estradiol (E2) stimulates cell proliferation in skeletal tissues, as measured by increased DNA synthesis and creatine kinase (CK) specific activity, and that calciotrophic hormones modulate E2 activity in rat osteoblastic sarcoma cells (ROS 17/2.8). Moreover, E2 failed to stimulate DNA synthesis in vitamin D-depleted female rat bone in the absence of prior i.p. injections of 1.25(OH)2D3. We have, therefore, studied the effects of pretreatment of… CONTINUE READING