Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels.

@article{Jin2002ReciprocalMB,
  title={Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels.},
  author={Ping Jin and Thomas M. Weiger and Irwin B. Levitan},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 46},
  pages={43724-9}
}
Large conductance Ca(2+)-dependent potassium (K(Ca) or maxi K) channels are composed of a pore-forming alpha subunit and an auxiliary beta subunit. We have shown that the brain-specific beta4 subunit modulates the voltage dependence, activation kinetics, and toxin sensitivity of the hSlo channel (Weiger, T. M., Holmqvist, M. H., Levitan, I. B., Clark, F. T., Sprague, S., Huang, W. J., Ge, P., Wang, C., Lawson, D., Jurman, M. E., Glucksmann, M. A., Silos-Santiago, I., DiStefano, P. S., and… CONTINUE READING