Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking

@article{Noda2008ReciprocalIW,
  title={Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking},
  author={Yumi Noda and Saburo Horikawa and Eiichiro Kanda and Maho Yamashita and Hu Meng and Kayoko Eto and Yuhua Li and Michio Kuwahara and Keiji Hirai and Changi Pack and Masataka Kinjo and Shigeo Okabe and Sei Sasaki},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={182},
  pages={587 - 601}
}
Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane and its vasopressin and protein kinase A (PKA)-dependent regulation in renal collecting ducts is critical for body water homeostasis. We previously identified an AQP2 binding protein complex including actin and tropomyosin-5b (TM5b). We show that dynamic interactions between AQP2 and the actin cytoskeleton are critical for initiating AQP2 apical targeting. Specific binding of AQP2 to G-actin in reconstituted liposomes is… CONTINUE READING
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Aquaporin - 2 traffi cking

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  • Endocrinology .
  • 2005

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