Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination

@article{Olgun2007ReciprocalIB,
  title={Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination},
  author={Hugo C. Olgu{\'i}n and Zhihong Yang and Stephen J. Tapscott and Bradley B Olwin},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={177},
  pages={769 - 779}
}
Postnatal growth and regeneration of skeletal muscle requires a population of resident myogenic precursors named satellite cells. The transcription factor Pax7 is critical for satellite cell biogenesis and survival and has been also implicated in satellite cell self-renewal; however, the underlying molecular mechanisms remain unclear. Previously, we showed that Pax7 overexpression in adult primary myoblasts down-regulates MyoD and prevents myogenin induction, inhibiting myogenesis. We show that… CONTINUE READING
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Pax7 and myogenic progression in skeletal muscle satellite cells.

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