Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells.

@article{Zhong2007ReciprocalGO,
  title={Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells.},
  author={Xuemei Zhong and Wenda Gao and Nicolas Degauque and Chunyan Bai and Yan Lu and James W. Kenny and Mohamed Oukka and Terry B. Strom and Thomas L. Rothstein},
  journal={European journal of immunology},
  year={2007},
  volume={37 9},
  pages={
          2400-4
        }
}
  • Xuemei Zhong, Wenda Gao, +6 authors Thomas L. Rothstein
  • Published in
    European journal of…
    2007
  • Biology, Medicine
  • Regulatory T (T(reg)) cells are indispensable for maintaining peripheral tolerance, whereas T helper (Th)1 and Th17 cells induce inflammation and tissue destruction. Using Foxp3-GFP knock-in mice, we report a novel regulatory role for B cell subsets in influencing the differentiation of T(reg) versus Th1/Th17 cells. Peritoneal B1 cells strongly promoted T cell proliferation and cytokine secretion when presenting nominal or allogeneic antigens, as compared to conventional follicular B (B2) cells… CONTINUE READING

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