Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis.

@article{Gribar2009ReciprocalEA,
  title={Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis.},
  author={Steven C. Gribar and Chhinder P. Sodhi and Ward M. Richardson and Rahul J. Anand and George K. Gittes and Maria F. Branca and Adam M Jakub and Xia-hua Shi and Sohail S Shah and John A. Ozolek and David J. Hackam},
  journal={Journal of immunology},
  year={2009},
  volume={182 1},
  pages={636-46}
}
Necrotizing enterocolitis (NEC) is a common and often fatal inflammatory disorder affecting preterm infants that develops upon interaction of indigenous bacteria with the premature intestine. We now demonstrate that the developing mouse intestine shows reciprocal patterns of expression of TLR4 and TLR9, the receptor for bacterial DNA (CpG-DNA). Using a novel ultrasound-guided in utero injection system, we administered LPS directly into the stomachs of early and late gestation fetuses to induce… CONTINUE READING