Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

@article{Bettelli2006ReciprocalDP,
  title={Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells},
  author={Estelle Bettelli and Yijun Carrier and Wenda Gao and Thomas Korn and Terry B. Strom and Mohamed Oukka and Howard L. Weiner and Vijay K. Kuchroo},
  journal={Nature},
  year={2006},
  volume={441},
  pages={235-238}
}
On activation, T cells undergo distinct developmental pathways, attaining specialized properties and effector functions. T-helper (TH) cells are traditionally thought to differentiate into TH1 and TH2 cell subsets. TH1 cells are necessary to clear intracellular pathogens and TH2 cells are important for clearing extracellular organisms. Recently, a subset of interleukin (IL)-17-producing T (TH17) cells distinct from TH1 or TH2 cells has been described and shown to have a crucial role in the… Expand
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