Reciprocal cross-talk between Nod2 and TAK1 signaling pathways.

  title={Reciprocal cross-talk between Nod2 and TAK1 signaling pathways.},
  author={Chuan-min Chen and Yusong Gong and Min Zhang and Jian-Jun Chen},
  journal={The Journal of biological chemistry},
  volume={279 24},
Mutations in the leucine-rich repeat (LRR) domain of Nod2 have been implicated in the pathogenesis of Crohn's disease, yet the function of Nod2 and regulation of the Nod2 pathway remain unclear. In this study, we determined that mitogen-activated protein kinase kinase transforming growth factor (TGF)-beta-activated kinase 1 (TAK1) interacts with Nod2 and is required for Nod2-mediated NF-kappaB activation. The dominant negative form of TAK1 abolished muramyl dipeptide-induced NF-kappaB… CONTINUE READING


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