Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its gamma subunit and transducin.

@article{Wensel1986ReciprocalCO,
  title={Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its gamma subunit and transducin.},
  author={Theodore G Wensel and Lubert Stryer},
  journal={Proteins},
  year={1986},
  volume={1 1},
  pages={90-9}
}
The switching on of the cGMP phosphodiesterase (PDE) in retinal rod outer segments by activated transducin (T alpha-GTP) is a key step in visual excitation. The finding that trypsin activates PDE (alpha beta gamma) by degrading its gamma subunit and the reversal of this activation by gamma led to the proposal that T alpha-GTP activates PDE by relieving an inhibitory constraint imposed by gamma (Hurley and Stryer: J. Biol. Chem. 257:11094-11099, 1982). We report here studies showing that the… CONTINUE READING