Reciprocal control of miR-197 and IL-6/STAT3 pathway reveals miR-197 as potential therapeutic target for hepatocellular carcinoma.

@article{Wang2015ReciprocalCO,
  title={Reciprocal control of miR-197 and IL-6/STAT3 pathway reveals miR-197 as potential therapeutic target for hepatocellular carcinoma.},
  author={Huamin Wang and Xiaoping Su and Mingjin Yang and Taoyong Chen and Jin Hou and Nan Li and Xuetao Cao},
  journal={Oncoimmunology},
  year={2015},
  volume={4 10},
  pages={e1031440}
}
Signal transducer and activator of transcription 3 (STAT3) is one of the key players in liver cancer. Increased levels of phosphorylated STAT3 (p-STAT3) have been detected in many cancers including hepatocellular carcinoma (HCC), and are usually associated with a more aggressive phenotype and poor prognosis. In addition to aberrant activation of STAT3, upregulation of total STAT3 was also detected in HCC, for which the underlying mechanisms and significance remain to be fully elucidated. Here… CONTINUE READING