Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness.

@article{Giannoni2010ReciprocalAO,
  title={Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness.},
  author={Elisa Giannoni and Francesca Bianchini and Lorenzo Masieri and Sergio Serni and Eugenio Torre and Lido Calorini and Paola Chiarugi},
  journal={Cancer research},
  year={2010},
  volume={70 17},
  pages={6945-56}
}
Although cancer-associated fibroblasts (CAF) are key determinants in the malignant progression of cancer, their functional contribution to this process is still unclear. Analysis of the mutual interplay between prostate carcinoma cells and CAFs revealed a mandatory role of carcinoma-derived interleukin-6 in fibroblast activation. In turn, activated fibroblasts through secretion of metalloproteinases elicit in cancer cells a clear epithelial-mesenchymal transition (EMT), as well as enhancement… CONTINUE READING