Reciprocal activation between CD4+ T cells and Kupffer cells during hepatic ischemia-reperfusion.

@article{Hanschen2008ReciprocalAB,
  title={Reciprocal activation between CD4+ T cells and Kupffer cells during hepatic ischemia-reperfusion.},
  author={Marc Hanschen and Stefan Zahler and Fritz Krombach and Andrej Khandoga},
  journal={Transplantation},
  year={2008},
  volume={86 5},
  pages={710-8}
}
BACKGROUND Mechanisms mediating CD4+ T-cell recruitment during alloantigen-independent hepatic ischemia-reperfusion (I/R) remain not fully understood. We hypothesized that Kupffer cells activate CD4+ T-cells in the postischemic liver, by the release of free oxygen radicals and cytokines. METHODS Recruitment of freshly isolated and fluorescence-labeled CD4+ T-cell was analyzed after hepatic I/R (90/30-120 min) using intravital microscopy in sham-operated mice, in mice after hepatic I/R and in… CONTINUE READING