Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

@article{Mucida2007ReciprocalTA,
  title={Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid},
  author={D. Mucida and Y. Park and Gisen Kim and O. Turovskaya and I. Scott and M. Kronenberg and H. Cheroutre},
  journal={Science},
  year={2007},
  volume={317},
  pages={256 - 260}
}
  • D. Mucida, Y. Park, +4 authors H. Cheroutre
  • Published 2007
  • Biology, Medicine
  • Science
  • The cytokine transforming growth factor–β (TGF-β) converts naïve T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-β has also been found to promote the differentiation of naïve T lymphocytes into proinflammatory IL-17 cytokine-producing T helper 17 (TH17) cells, which promote autoimmunity and inflammation. This raises the question of how TGF-β can generate such distinct outcomes. We identified the vitamin A metabolite… CONTINUE READING
    1,771 Citations
    Regulatory T cells: Reciprocal regulation by retinoic acid
    • O. Leavy
    • Biology
    • Nature Reviews Immunology
    • 2007
    TGFβ and Retinoic Acid Intersect in Immune-Regulation
    • 45
    Retinoic acid in mucosal immune-regulation
    Transcriptional regulation of Th17 cell differentiation.
    • 410
    Th17 cells: The emerging reciprocal partner of regulatory T cells in the liver
    • 44
    TGF-β function in immune suppression.
    • 120
    Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10.
    • 397
    • Highly Influenced
    • PDF
    Th17 cells in inflammation.
    • 77

    References

    SHOWING 1-10 OF 17 REFERENCES
    Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
    • 1,345
    • PDF