Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

  title={Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid},
  author={D. Mucida and Y. Park and Gisen Kim and O. Turovskaya and I. Scott and M. Kronenberg and H. Cheroutre},
  pages={256 - 260}
  • D. Mucida, Y. Park, +4 authors H. Cheroutre
  • Published 2007
  • Biology, Medicine
  • Science
  • The cytokine transforming growth factor–β (TGF-β) converts naïve T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-β has also been found to promote the differentiation of naïve T lymphocytes into proinflammatory IL-17 cytokine-producing T helper 17 (TH17) cells, which promote autoimmunity and inflammation. This raises the question of how TGF-β can generate such distinct outcomes. We identified the vitamin A metabolite… CONTINUE READING
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